Homepage
     
SERVICES in ADME-Tox
  ADME  
  Toxicology  
  V79 Cell Battery™  
  Analytical Services  
  Service Packages  
  Partnered Services  
 

GenPharmTox BioTech AG
phone: +49 (0) 89 89 55 59 - 0
eMail: info@genpharmtox.de
 
About us References Career News Publications Links Contact
Home   Imprint

V79 Cell BatteryTM

GenPharmTox BioTech AG offers many of its contract services using the unique V79 Cell BatteryTM.
The V79 Cell BatteryTM consists of a panel of recombinant V79 cell lines expressing a broad range of phase I- and / or phase II-enzymes relevant in the metabolism of xenobiotics.
GenPharmTox also provides cell homogenate and subcellular fractions of these recombinant V79 cell lines.

V79 cells provide unique biological properties:

  • stable diploide karyotype
  • cloning efficiency >90%
  • doubling time <12 h
  • stable morphology, robust culture
  • no CYP background activity
  • proven in toxicology since the 1960's
  • recommended by the OECD guidelines


These properties make the V79 Cell BatteryTM an unique in vitro test system:

  • Humanized: Humanized systems guarantee high predicitivity of in vitro results for the human situation
  • Integrated: Integrated system with identical location of metabolism and toxicological endpoint
  • Specific: Specificity enables to clarify metabolic pathways as well as mechanisms in toxicology
  • Standardised: Standardised systems guarantee high reproducibility
  • Easy to use: Stable and reproducible homogenous systems
  • Economic: Excellent cost / benefit ratio due to improved data quality with high predictive value for the human situation

"A number of developments, including the construction of genetically engineered cell lines expressing specific activating enzymes, may provide the potential for endogenous activation. The choice of the cell lines used should be scientifically justified (e.g. by the relevance of the cytochrome P450 isoenzymes for the metabolism of the test substance)."

OECD recommendations


up

GenPharmTox BioTech AG • phone: +49 (0) 89 89 55 59-0 • fax: +49 (0) 89 89 55 59-18 • eMail: info@genpharmtox.de

PDF Download
V79 Cell Battery™
[size 57 KB]
Catalogue Services in ADME-Tox
[size 323 KB]


“As an innovative company we need a partner who fits in with our philosophy. GenPharmTox is a reliable, competent and brisk partner in realisation of our new development projects.”

Dr.Thomas Kronbach, elbion AG