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GenPharmTox BioTech AG
phone: +49 (0) 89 89 55 59 - 0
eMail: info@genpharmtox.de
 
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Chromosome Aberration Test

The chromosome aberration test (mutagenicity: in vitro mammalian cytogenetic test) is performed according to OECD guideline 473. Screening and ranking study designs are also available.

Standard Chromosome Aberration Test (OECD 473)


Quantity of test item required: 3 g
Turnaround time of draft report : 30 working days


Study Design

  • cytotoxicity and range finding pre-test
  • V79 cells
  • three dose levels
  • minimum of two replicates per dose level
  • with and without rat S9
  • incubation time: 3 h w and w/o S9, 24 h w/o S9
  • negative control
  • positive control
  • evaluation of 200 metaphases per concentration


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GenPharmTox BioTech AG • phone: +49 (0) 89 89 55 59-0 • fax: +49 (0) 89 89 55 59-18 • eMail: info@genpharmtox.de

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