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GenPharmTox BioTech AG
phone: +49 (0) 89 89 55 59 - 0
eMail: info@genpharmtox.de
 
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HIV-I / AIDS

The HIV-I / AIDS services are offered in co-operation with VivaCell.

HIV-I / AIDS: in vitro Services

In vitro testing methods include cell lines specific for HIV-I studies.

Models

  • Jurkat cells stably transfered with the luciferase gene directed by the LTR-HIV promoter
  • MT-2 cells for infection with the HIV-I virus
  • Tat-transfected cells, in vitro infection pf primary T cells
  • determination of IC-50 for anti-HIV drugs using an artificial proviral clone


Parameters

  • inhibition of cell death by HIV-I in MT-2 cells (MTT assays)
  • determination of p24 antigen in culture supernatants of primary T cells infected with HIV-I
  • determination of the transcriptional activity of the LTR-HIV promoter by Tat and by TNFa
  • determination of anti-HIV compounds targeting Tat/TAR interaction and RNA elongation
  • determination of viral package in 293T cells

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GenPharmTox BioTech AG • phone: +49 (0) 89 89 55 59-0 • fax: +49 (0) 89 89 55 59-18 • eMail: info@genpharmtox.de

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