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GenPharmTox BioTech AG
phone: +49 (0) 89 89 55 59 - 0
eMail: info@genpharmtox.de
 
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Central Nervous System

The CNS services are offered in co-operation with VivaCell.

CNS: in vitro Services

Assays for the investigation of inflammation, pain, fever, depression and neurodegenerative disorders like Alzheimer's disease, multiple sclerosis, etc. are offered.

Models

  • primary microglia / astrocytes / neurons (rat, murine)
  • U373 MG (human astrocytes cell line), human neuronal cll lines
  • brain slice cultures
  • 293T and CHO cells with heterologue expression of the Vanilloid Receptor type I (VR-1)

Parameters

  • Prostaglandis (e.g. PGE2), cyclooxygenase expression and activity (COX-1, COX-2)
  • iNOS / NO release
  • cytokines (TNF-a, IL-6, etc.)
  • growth factors (NGF, etc.)
  • neuropeptides (substance P, etc.)
  • transcription factors (NF-kB / IkB, AP-1, STATs, etc.)
  • kinases (Erks, Protein kinase C, Jun, p38 MAP, etc.)
  • neurotransmitters (e.g. serotonin, noradrenalin, dopamin re-uptake)
  • proteasome activity
  • calcium mobilization, cytotoxicity and apoptosis, determination of ROS and mitochondria transmembrane potential
  • agoinst and antagoinst of the VR-1 for non-opiaceus analgesic pharmacophores
  • receptor assays (screening, membrane preparations, cells, dose-response)

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GenPharmTox BioTech AG • phone: +49 (0) 89 89 55 59-0 • fax: +49 (0) 89 89 55 59-18 • eMail: info@genpharmtox.de

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