Homepage
     
SERVICES in ADME-Tox
  ADME  
  Toxicology  
  V79 Cell Battery™  
  Analytical Services  
  Service Packages  
  Partnered Services  
 

GenPharmTox BioTech AG
phone: +49 (0) 89 89 55 59 - 0
eMail: info@genpharmtox.de
 
About us References Career News Publications Links Contact
Home   Imprint

Species Comparison and Metabolite Profiling

The metabolic stability and metabolite profile of the test item is investigated and compared with respect to different species in vitro. The data obtained provide valuable information for species selection in toxicological studies in vivo.

Study Outline


Quantity of test item required: 10 mg/species
Turnaround time of draft report: 20-30 working days


Study Design

  • range finding
  • triplicates
  • one concentration of test system
  • one concentration of test item
  • one to six time points
  • positive control: formation of 7-hydroxycoumarin and/or selected phase I and /or phase II marker reactions
  • negative control: zero time point and/or no NADPH
  • TI blank (no test item)
  • TS blank (no test item)
  • TITS blank (no test item, no test system

Analytics

  • HPLC-DAD/FLD or LC-MS/MS or Radiodetection:
    loss of parent compound and /or formation of selected metabolites and/or identification of major phase I oxidative metabolites and/or major phase II conjugates by mass relative to the parent compound

« back
GenPharmTox BioTech AG • phone: +49 (0) 89 89 55 59-0 • fax: +49 (0) 89 89 55 59-18 • eMail: info@genpharmtox.de

PDF Download
Metabolite Profiling
[size 63 KB]
   
ADME
[size 129 KB]
Catalogue Services in ADME-Tox
[size 323 KB]