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eMail: info@genpharmtox.de
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CYP Profiling

Identification of CYP isoforms involved in the metabolism of the test item in vitro.

Human Recombinant Enzymes

The "percentage metabolism" of the test item with respect to different human recombinant CYP isoenzymes is determined.

Quantity of test item required: 15 mg
Turnaround time of draft report: 15 working days

Study Design

  • nine CYP isoenzymes:
    1A2, 2A6, 2B6, 2C8, 2C9, 2C19, 2D6, 2E1, 3A4
    please inquire for further CYP-isoforms
  • triplicates
  • one concentration of CYP
  • one concentration of test item
  • one time point
  • positive control: CYP marker reaction
  • negative control: non-expressing control


  • HPLC-DAD/FLD or LC-MS/MS or Radiodetection:
    loss of parent compound and/or formation of selected metabolites and/or identification of major oxidative metabolites by mass relative to the parent compound

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GenPharmTox BioTech AG • phone: +49 (0) 89 89 55 59-0 • fax: +49 (0) 89 89 55 59-18 • eMail: info@genpharmtox.de

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