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GenPharmTox BioTech AG
phone: +49 (0) 89 89 55 59 - 0
eMail: info@genpharmtox.de
 
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CYP Profiling

Identification of CYP isoforms involved in the metabolism of the test item in vitro.

Correlation Analysis

The CYP isoenzymes involved in the in vitro metabolism of the test item are identified by correlation analysis using individual human liver microsomes. The inter-individual rate of metabolism of the test item is compared to the variation in the rate of a set of CYP marker reactions. The respective correlation coefficients are determined.


Quantity of test item required: 15 mg
Turnaround time of draft report: 15 working days


Study Design

  • range finding (optional)
  • triplicates
  • 16 individual human liver microsomal samples (one concentration)
  • one time point
  • positive control: CYP marker reaction
  • negative control: zero time point and/or no NADPH

Analytics

  • HPLC-DAD/FLD or LC-MS/MS or Radiodetection: loss of parent compound and/or formation of selected metabolites and/or identification of major oxidative metabolites by mass relative to the parent compound

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GenPharmTox BioTech AG • phone: +49 (0) 89 89 55 59-0 • fax: +49 (0) 89 89 55 59-18 • eMail: info@genpharmtox.de

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