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Publications

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2007

Carmo H, Brulport M, Hermes M, Oesch F, de Boer D, Remiao F, Carvalho F, Schon MR, Krebsfaenger N, Doehmer J, Bastos Mde L, Hengstler JG.

CYP2D6 increases toxicity of the designer drug 4-methylthioamphetamine (4-MTA).

[Toxicology. 2007 Jan 18;229(3):236-44. Epub 2006 Dec 5. ]

Mahadevan B, Marston CP, Luch A, Dashwood WM, Brooks E, Pereira C, Doehmer J, Baird WM.

Competitive inhibition of carcinogen-activating CYP1A1 and CYP1B1 enzymes by a standardized complex mixture of PAH extracted from coal tar.

[Int J Cancer. 2007 March 15;120(6):1161-8.]
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2006

Peng FC, Chang CC, Yang CY, Edwards RJ, Doehmer J.

Territrems B and C metabolism in human liver microsomes: major role of CYP3A4 and CYP3A5.

[Toxicology. 2006 Feb 1;218(2-3):172-85. Epub 2005 Dec 5. ]

Schober W, Luch A, Soballa VJ, Raab G, Stegeman JJ, Doehmer J, Jacob J, Seidel A.

On the species-specific biotransformation of dibenzo[a,l]pyrene.

[Chem Biol Interact. 2006 May 15;161(1):37-48. Epub 2006 Apr 11.]

Kushman ME, Kabler SL, Fleming MH, Ravoori S, Gupta RC, Doehmer J, Morrow CS, Townsend AJ

Expression of human glutathione S-transferase P1 confers resistance to benzo[a]pyrene or benzo[a]pyrene-7,8-dihydrodiol mutagenesis, macromolecular alkylation, and formation of stable N2-Gua-BPDE adducts in stably transfected V79MZ cells co-expressing hCYP1A1.

[Carcinogenesis. 2007 Jan;28(1):207-14. Epub 2006 Aug 2.]

Carmo H, Brulport M, Hermes M, Oesch F, Silva R, Ferreira LM, Branco PS, Boer DD, Remiao F, Carvalho F, Schon MR, Krebsfaenger N, Doehmer J, Bastos MD, Hengstler JG

Influence of CYP2D6 polymorphism on 3,4-methylenedioxymethamphetamin ('Ecstasy') cytotoxicity

[Pharmacogenet Genomics. 2006 Nov;16(11):789-799]

Doehmer J.

Predicting drug metabolism-dependent toxicity for humans with a genetically engineered cell battery.

[Altern Lab Anim. 2006 Dec;34(6):561-75]
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2005

Scheuenpflug J, Krebsfanger N, Doehmer J.

Heterologous co-expression of human cytochrome P450 1A2 and polymorphic forms of N-acetyltransferase 2 for studies on aromatic amines in V79 Chinese hamster cells.

[Altern Lab Anim. 2005 Dec;33(6):561-77. ]
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2004

Boyce A, Doehmer J, Gooderham NJ.

Phytoalexin resveratrol attenuates the mutagenicity of the heterocyclic amines 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline.

[J Chromatogr B Analyt Technol Biomed Life Sci. 2004 Mar 25;802(1):217-23.]

Westerholt A, Himpel S, Hager-Gensch B, Maier S, Werner M, Stadler J, Doehmer J, Heidecke CD.

Intragraft iNOS induction during human liver allograft rejection depresses cytochrome p450 activity.

[Transpl Int. 2004 Aug;17(7):370-8. Epub 2004 Jul 29.]
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2003

Coller, J. K.; Krebsfaenger, N.; Klein, K.; Wolbold, R.; Nuessler, A.; Neuhaus, P.; Zanger, U. M.; Eichelbaum, M.; Muerdter, T. E.

Large interindividual variability in the in vitro formation of tamoxifen metabolites related to the development of genotoxicity.

[Br J Clin Pharmacol. 2004 Jan;57(1):105-11]

Krebsfaenger, N.; Muerdter, T. E.; Zanger, U. M.; Eichelbaum, M. F.; Doehmer, J.

V79 Chinese hamster cells genetically engineered for polymorphic cytochromes P450 2D6 and their predictive value for humans.

[ALTEX 2003;20(3):143-54]
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2002

Coller, J. K.; Krebsfaenger, N.; Klein, K.; Endrizzi, K.; Wolbold, R.; Lang, T.; Nuessler, A.; Neuhaus, P.; Zanger, U. M.; Eichelbaum, M.; Muerdter, T. E.

The influence of CYP2B6, CYP2C9 and CYP2D6 genotypes on the formation of the potent antioestrogen Z-4-hydroxy-tamoxifen in human liver.

[Br. J. Clin. Pharmacol. 2002 (54), 157-167]

Lautraite S, Musonda AC, Doehmer J, Edwards GO, Chipman JK.

Flavonoids inhibit genetic toxicity produced by carcinogens in cells expressing CYP1A2 and CYP1A1.

[Mutagenesis. 2002 Jan;17(1):45-53.]
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2001

McFadyen MC, McLeod HL, Jackson FC, Melvin WT, Doehmer J, Murray GI.

Cytochrome P450 CYP1B1 protein expression: a novel mechanism of anticancer drug resistance.

[Biochem Pharmacol. 2001 Jul 15;62(2):207-12]

Doehmer J.

Modern drug development by molecular- and cell-biological methods

[ALTEX. 2001;18(1):9-12]

Schleger, C.; Krebsfaenger, N.; Kalkuhl, A.; Bader, R.; Singer, T. (2001)

Innovative cell culture methods in drug development.

[ALTEX 2001, 18(1): 5-8]
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2000

Thatcher NJ, Edwards RJ, Lemoine NR, Doehmer J, Davies DS.

The potential of acetaminophen as a prodrug in gene-directed enzyme prodrug therapy.

[Cancer Gene Ther. 2000 Apr;7(4):521-5]
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1999

Luch A, Kishiyama S, Seidel A, Doehmer J, Greim H, Baird WM.

The K-region trans-8,9-diol does not significantly contribute as an intermediate in the metabolic activation of dibenzo[a,l]pyrene to DNA-binding metabolites by human cytochrome P450 1A1 or 1B1.

[Cancer Res. 1999 Sep 15;59(18):4603-9]

Simi S, Xiao Y, Campagna M, Doehmer J, Darroudi F.

Dual-colour FISH analysis to characterize a marker chromosome in cytochrome P450 2B1 recombinant V79 Chinese hamster cells.

[Mutagenesis. 1999 Jan;14(1):57-61]

Engst W, Landsiedel R, Hermersdorfer H, Doehmer J, Glatt H.

Benzylic hydroxylation of 1-methylpyrene and 1-ethylpyrene by human and rat cytochromes P450 individually expressed in V79 Chinese hamster cells.

[Carcinogenesis. 1999 Sep;20(9):1777-85.]

Fields WR, Morrow CS, Doehmer J, Townsend AJ.

Expression of stably transfected murine glutathione S-transferase A3-3 protects against nucleic acid alkylation and cytotoxicity by aflatoxin B1 in hamster V79 cells expressing rat cytochrome P450-2B1.

[Carcinogenesis. 1999 Jun;20(6):1121-5]

Buters JT, Doehmer J, Gonzalez FJ.

Cytochrome P450-null mice.

[Drug Metab Rev. 1999 May;31(2):437-47. Review.]

Doehmer J, Buters JT, Luch A, Soballa V, Baird WM, Morisson H, Stegeman JJ, Townsend AJ, Greenlee WF, Glatt HR, Seidel A, Jacob J, Greim H.

Molecular studies on the toxifying effects by genetically engineered cytochromes P450.

[Drug Metab Rev. 1999 May;31(2):423-35. Review.]

Luch A, Kudla K, Seidel A, Doehmer J, Greim H, Baird WM.

The level of DNA modification by (+)-syn-(11S,12R,13S,14R)- and (-)-anti-(11R,12S,13S,14R)-dihydrodiol epoxides of dibenzo[a,l]pyrene determined the effect on the proteins p53 and p21WAF1 in the human mammary carcinoma cell line MCF-7.

[Carcinogenesis. 1999 May;20(5):859-65.]

Luch A, Schober W, Soballa VJ, Raab G, Greim H, Jacob J, Doehmer J, Seidel A.

Metabolic activation of dibenzo[a,l]pyrene by human cytochrome P450 1A1 and P450 1B1 expressed in V79 Chinese hamster cells.

[Chem Res Toxicol. 1999 Apr;12(4):353-64.]

Townsend AJ, Fields WR, Doss AJ, Clapper ML, Doehmer J, Morrow CS.

Modeling the chemoprotective functions of glutathione S-transferases in cultured cell lines by heterologous expression.

[Drug Metab Rev. 1999 Feb;31(1):43-69. Review.]

Buters JT, Sakai S, Richter T, Pineau T, Alexander DL, Savas U, Doehmer J, Ward JM, Jefcoate CR, Gonzalez FJ.

Cytochrome P450 CYP1B1 determines susceptibility to 7, 12-dimethylbenz[a]anthracene-induced lymphomas.

[Proc Natl Acad Sci U S A. 1999 Mar 2;96(5):1977-82.]

Philip PA, Ali-Sadat S, Doehmer J, Kocarek T, Akhtar A, Lu H, Chan KK.

Use of V79 cells with stably transfected cytochrome P450 cDNAs in studying the metabolism and effects of cytotoxic drugs.

[Cancer Chemother Pharmacol. 1999;43(1):59-67.]
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1998

Townsend AJ, Fields WR, Haynes RL, Doss AJ, Li Y, Doehmer J, Morrow CS.

Chemoprotective functions of glutathione S-transferases in cell lines induced to express specific isozymes by stable transfection.

[Chem Biol Interact. 1998 Apr 24;111-112:389-407.]

Luch A, Coffing SL, Tang YM, Schneider A, Soballa V, Greim H, Jefcoate CR, Seidel A, Greenlee WF, Baird WM, Doehmer J.

Stable expression of human cytochrome P450 1B1 in V79 Chinese hamster cells and metabolically catalyzed DNA adduct formation of dibenzo[a,l]pyrene.

[Chem Res Toxicol. 1998 Jun;11(6):686-95.]
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1996

Schmalix WA, Lang D, Schneider A, Bocker R, Greim H, Doehmer J.

Stable expression and coexpression of human cytochrome P450 oxidoreductase and cytochrome P450 1A2 in V79 Chinese hamster cells: sensitivity to quinones and biotransformation of 7-alkoxyresorufins and triazines.

[Drug Metab Dispos. 1996 Dec;24(12):1314-9.]

Onderwater RC, Goeptar AR, Levering PR, Vos RM, Konings PN, Doehmer J, Commandeur JN, Vermeulen NP.

The use of macroporous microcarriers for the large-scale growth of V79 cells genetically designed to express single human cytochrome P450 isoenzymes and for the characterization of the expressed cytochrome P450.

[Protein Expr Purif. 1996 Dec;8(4):439-46.]

Schmalix WA, Singh JJ, Kapfhammer P, Stadler J, Nussler AK, Geller DA, Billiar TR, Simmons RL, Greim H, Doehmer J.

Stable expression of human inducible nitric oxide synthase in V79 Chinese hamster cells.

[Biochem Pharmacol. 1996 Nov 8;52(9):1365-74.]

Schneider A, Schmalix WA, Siruguri V, de Groene EM, Horbach GJ, Kleingeist B, Lang D, Bocker R, Belloc C, Beaune P, Greim H, Doehmer J.

Stable expression of human cytochrome P450 3A4 in conjunction with human NADPH-cytochrome P450 oxidoreductase in V79 Chinese hamster cells.

[Arch Biochem Biophys. 1996 Aug 15;332(2):295-304.]

Jensen KG, Poulsen HE, Doehmer J, Loft S.

Paracetamol-induced spindle disturbances in V79 cells with and without expression of human CYP1A2.

[Pharmacol Toxicol. 1996 Apr;78(4):224-8.]

Shaw PM, Edigkaufer M, Doehmer J, Adesnik M.

Sequence of the rat PB-inducible CYP2B1 promoter.

[Biochim Biophys Acta. 1996 Feb 7;1305(1-2):54-8.]

Stadler J, Schmalix WA, Doehmer J.

Inhibition of cytochrome P450 enzymes by nitric oxide.

[Adv Exp Med Biol. 1996;387:187-93. Review.]
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1995

Doehmer J, Schneider A, Fassbender M, Soballa V, Schmalix WA, Greim H.

Genetically engineered mammalian cells and applications.

[Toxicol Lett. 1995 Dec;82-83:823-7.]

Goeptar AR, te Koppele JM, Glatt HR, Groot EJ, Seidel A, Barrenscheen M, Wolfel C, Doehmer J, Vermeulen NP.

The cytotoxicity of mitomycin C and adriamycin in genetically engineered V79 cell lines and freshly isolated rat hepatocytes.

[Chem Biol Interact. 1995 Jul 14;97(2):149-68.]

Denner K, Vogel R, Schmalix W, Doehmer J, Bernhardt R.

Cloning and stable expression of the human mitochondrial cytochrome P45011B1 cDNA in V79 Chinese hamster cells and their application for testing of potential inhibitors.

[Pharmacogenetics. 1995 Apr;5(2):89-96.]

Jensen KG, Poulsen HE, Doehmer J, Loft S.

Kinetics and inhibition by fluvoxamine of phenacetin O-deethylation in V79 cells expressing human CYP1A2.

[Pharmacol Toxicol. 1995 Apr;76(4):286-8.]

Denner K, Doehmer J, Bernhardt R.

Cloning of CYP11B1 and CYP11B2 from normal human adrenal and their functional expression in COS-7 and V79 Chinese hamster cells.

[Endocr Res. 1995 Feb-May;21(1-2):443-8.]

Schmalix WA, Doehmer J.

Use of recombinant cells in metabolic and mechanistic studies.

[Arch Toxicol Suppl. 1995;17:8-22. Review.]

Doehmer J, Holtkamp D, Soballa V, Raab G, Schmalix W, Seidel A, Greim H, Jacob J.

Cytochrome P450 mediated reactions studied in genetically engineered V79 Chinese hamster cells.

[Pharmacogenetics. 1995;5 Spec No:S91-6.]
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1994

Doehmer J, Jacob J.

Gentecnically engineered V79 cell lines in combination with analytical-chemical procedures for replacing and refining animal experimentations

[ALTEX. 1994;11(3):141-147.]

Kasper R, Gansser D, Doehmer J.

Biotransformation of the naturally occurring lignan (-)-arctigenin in mammalian cell lines genetically engineered for expression of single cytochrome P450 isoforms.

[Planta Med. 1994 Oct;60(5):441-4.]

Kiefer F, Cumpelik O, Reen R, Doehmer J, Wiebel FJ.

Arylamines suppress their own activation and that of nitroarenes in V79 Chinese hamster cells by competing for acetyltransferases.

[Environ Health Perspect. 1994 Oct;102 Suppl 6:95-7.]

Doehmer J, Schmalix WA, Greim H.

Genetically engineered in vitro systems for biotransformation studies.

[Methods Find Exp Clin Pharmacol. 1994 Sep;16(7):513-8. Review.]

Stadler J, Trockfeld J, Schmalix WA, Brill T, Siewert JR, Greim H, Doehmer J.

Inhibition of cytochromes P4501A by nitric oxide.

[Proc Natl Acad Sci U S A. 1994 Apr 26;91(9):3559-63.]
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1993

Vang O, Wallin H, Doehmer J, Autrup H.

Cytochrome P450-mediated metabolism of tumour promoters modifies the inhibition of intercellular communication: a modified assay for tumour promotion.

[Carcinogenesis. 1993 Nov;14(11):2365-71.]

Fuhr U, Doehmer J, Battula N, Wolfel C, Flick I, Kudla C, Keita Y, Staib AH.

Biotransformation of methylxanthines in mammalian cell lines genetically engineered for expression of single cytochrome P450 isoforms. Allocation of metabolic pathways to isoforms and inhibitory effects of quinolones.

[Toxicology. 1993 Oct 5;82(1-3):169-89.]

Doehmer J.

V79 Chinese hamster cells genetically engineered for cytochrome P450 and their use in mutagenicity and metabolism studies.

[Toxicology. 1993 Oct 5;82(1-3):105-18. Review.]

Schmalix WA, Maser H, Kiefer F, Reen R, Wiebel FJ, Gonzalez F, Seidel A, Glatt H, Greim H, Doehmer J.

Stable expression of human cytochrome P450 1A1 cDNA in V79 Chinese hamster cells and metabolic activation of benzo[a]pyrene.

[Eur J Pharmacol. 1993 Oct 1;248(3):251-61.]

Jensen KG, Onfelt A, Poulsen HE, Doehmer J, Loft S.

Effects of benzo[a]pyrene and (+-)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene on mitosis in Chinese hamster V79 cells with stable expression of rat cytochrome P4501A1 or 1A2.

[Carcinogenesis. 1993 Oct;14(10):2115-8.]

Kulka U, Doehmer J, Glatt HR, Bauchinger M.

Cytogenetic effects of promutagens in genetically engineered V79 Chinese hamster cells expressing cytochromes P450.

[Eur J Pharmacol. 1993 Apr 1;228(5-6):299-304.]

Jensen KG, Loft S, Doehmer J, Poulsen HE.

Metabolism of phenacetin in V79 Chinese hamster cell cultures expressing rat liver cytochrome P4501A2 compared to isolated rat hepatocytes.

[Biochem Pharmacol. 1993 Mar 9;45(5):1171-3.]

Doehmer J, Goeptar AR, Vermeulen NP.

Cytochromes P450 and drug resistance.

[Cytotechnology. 1993;12(1-3):357-66. Review.]
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1992

Doehmer J, Wolfel C, Dogra S, Doehmer C, Seidel A, Platt KL, Oesch F, Glatt HR.

Applications of stable V79-derived cell lines expressing rat cytochromes P4501A1, 1A2, and 2B1.

[Xenobiotica. 1992 Sep-Oct;22(9-10):1093-9.]

Fuhr U, Doehmer J, Battula N, Wolfel C, Kudla C, Keita Y, Staib AH.

Biotransformation of caffeine and theophylline in mammalian cell lines genetically engineered for expression of single cytochrome P450 isoforms.

[Biochem Pharmacol. 1992 Jan 22;43(2):225-35.]
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1991

Doehmer J, Barrenscheen M, Dogra S, Edigkaufer M, Giatt H, Oesch F, Platt KL, Seidel A, Wolfel C.

Genetically engineered V79 Chinese hamster cells for stable expression of xenobiotics metabolising enzymes

[ALTEX. 1991;8(2):52-65.]

Ellard S, Mohammed Y, Dogra S, Wolfel C, Doehmer J, Parry JM.

The use of genetically engineered V79 Chinese hamster cultures expressing rat liver CYP1A1, 1A2 and 2B1 cDNAs in micronucleus assays.

[Mutagenesis. 1991 Nov;6(6):461-70.]

Wolfel C, Platt KL, Dogra S, Glatt H, Wachter F, Doehmer J.

Stable expression of rat cytochrome P450IA2 cDNA and hydroxylation of 17 beta-estradiol and 2-aminofluorene in V79 Chinese hamster cells.

[Mol Carcinog. 1991;4(6):489-98.]

Doehmer J, Oesch F.

V79 Chinese hamster cells genetically engineered for stable expression of cytochromes P450.

[Methods Enzymol. 1991;206:117-23.]
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1990

Doehmer J, Seidel A, Oesch F, Glatt HR.

Genetically engineered V79 Chinese hamster cells metabolically activate the cytostatic drugs cyclophosphamide and ifosfamide.

[Environ Health Perspect. 1990 Aug;88:63-5.]

Oesch F, Doehmer J, Friedberg T, Glatt HR, Oesch-Bartlomowicz B, Platt KL, Steinberg P, Utesch D, Thomas H.

Toxicological implications of enzymatic control of reactive metabolites.

[Hum Exp Toxicol. 1990 May;9(3):171-7. ]

Dogra S, Doehmer J, Glatt H, Molders H, Siegert P, Friedberg T, Seidel A, Oesch F.

Stable expression of rat cytochrome P-450IA1 cDNA in V79 Chinese hamster cells and their use in mutagenicity testing.

[Mol Pharmacol. 1990 May;37(5):608-13.]

Oesch F, Doehmer J, Friedberg T, Glatt H, Oesch-Bartlomowicz B, Platt KL, Steinberg P, Utesch D, Thomas H.

Control of ultimate mutagenic species by diverse enzymes.

[Prog Clin Biol Res. 1990;340B:49-65.]
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1989

Waxman DJ, Lapenson DP, Morrissey JJ, Park SS, Gelboin HV, Doehmer J, Oesch F.

Androgen hydroxylation catalysed by a cell line (SD1) that stably expresses rat hepatic cytochrome P-450 PB-4 (IIB1).

[Biochem J. 1989 May 15;260(1):81-5.]

Doehmer J, Dogra S, Edigkaufer M, Molitor E, Siegert P, Friedberg T, Glatt H, Platt K, Seidel A, Thomas H, et al.

Introduction of cytochrome P-450 genes into V79 Chinese hamster cells to generate new mutagenicity test systems.

[Arch Toxicol Suppl. 1989;13:164-8. Review.]
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1988

Doehmer J, Dogra S, Friedberg T, Monier S, Adesnik M, Glatt H, Oesch F.

Stable expression of rat cytochrome P-450IIB1 cDNA in Chinese hamster cells (V79) and metabolic activation of aflatoxin B1.

[Proc Natl Acad Sci U S A. 1988 Aug;85(16):5769-73.]

1987

Glatt H, Gemperlein I, Turchi G, Heinritz H, Doehmer J, Oesch F.

Search for cell culture systems with diverse xenobiotic-metabolizing activities and their use in toxicological studies.

[Mol Toxicol. 1987-88 Fall;1(4):313-34. Review.]
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